ALP can help diagnose cholestasis, but it is not liver specific in most animals. It is also found in bone, intestine, kidney, mammary and placental tissues. So when ALP is elevated the origin could be in the liver or any of these other tissues.
ALP elevation may be caused by:
-Cholestasis
-Liver disease
-Bone disease: increased osteoblastic activity due to hyperparathyroidism, osteosarcoma, a healing fracture (in dogs).
-Increased cortisol: due to steroid administration (such as prednisone) or due to Cushings (hyperadrenocorticism). This is less likely in cats
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