Globulins are the second most common protein in serum or plasma. They are responsible for the body's immune functions.
Increased globulins or "hyperglobulinemia" may result from:
-Immune system stimulation: from infection or allergies.
-Stress
-Dehydration: this is a relative increase meaning that the amount of globulin is normal, but it is more concentrated due to the lack of water. This is likely the case if albumin is also increased.
-Liver disease
-Heart disease
-Arthritis
-Diabetes
Decreased globulins may result from:
-Immune system suppression: due to corticosteroid use,r stress, or infectious disease.
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