MCHC or Mean Corpuscular Hemoglobin Concentration is the average amount of hemoglobin in the red blood cells. It is usually a machine-determined value, but it can be estimated like this:
MCHC = (Hb / PCV) X 100
Increased MCHC:
-Machine error: there is no such thing as hyperchromic RBC's
Decreased MCHC:-Regenerative anemia: immature cells have less hemoglobin than mature cells, so a low MCHC can indicate regenerative anemia. MCV, reticulocytes, and nRBC's should also be looked at as well to confirm that the cause of the low MCHC is regenerative anemia.
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